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When converted to hydroxyl, hydrogen peroxide is able to cross membranes, and ozone is a powerful oxidant of lipid chains, as well as it is able to interact with different organic and inorganic substances, in addition to generating other free radicals (Bensakhria 2018)

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There is a need to reassess this important class of drugs, and to reconcile the discordance between the historic success of covalent drugs and the reluctance of most drug discovery teams to include them in their armamentarium