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Molecular and biochemical aspects of the neuroprotective effect of the selective estrogen receptor modulator tamoxifen in a model of acute cerebral ischemia

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This remains an area of active investigation rather than settled science

On the one hand, GPX4 is transcriptionally regulated

Concurrently, exercise alleviates oxidative stress-induced damage to myocytes by improving mitochondrial function and reducing excessive ROS production, thereby breaking the vicious cycle of inflammation-oxidative stress-muscle loss (38, 55, 60)