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In contrast, in the randomized, placebo-controlled study in 251 patients with STEMI undergoing primary angioplasty discussed in the previous section, high-dose NAC (1200 mg IV bolus twice daily intravenously for 48 hours) was associated with a numerically lower incidence of CIN in patients treated with NAC versus placebo (14% vs

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Recently, several therapies targeting CAFs associated signal molecules have been developed, including TGF- inhibitors, PDGF inhibitor, Hedgehog inhibitors, FAK inhibitors and IL-6 inhibitors

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