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These substitutions are theorized to help resist enzymatic degradation, minimize oxidation, and maintain more consistent signaling patterns when compared with naturally occurring GHRH fragments

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Microbiology 155, 513520

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Furthermore, evidence from human research clearly shows both that a significant proportion of the populations of developed countries suffer from deficiencies or insufficiencies in one or more of this group of vitamins, and that, in the absence of an optimal diet, administration of the entire B-vitamin group, rather than a small sub-set, at doses greatly in excess of the current governmental recommendations, would be a rational approach for preserving brain health