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In separate assays, serum-starved PC3 cells were transfected with AR-Flag variant 2 and pmCherry or pmCherry-RanQ69L and treated with Sema4D-Fc (2 g/ml, Bio-techne), DHT (Sigma) or vehicle control for 1.5 h or 1 h respectively

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doi: 10.1038/s41598-025-92868-y 74 PereiraAGEchaveJJorgeAOSNogueira-MarquesRNur YuksekEBarcielaPet al

A deeper understanding of mitochondrial and oxidative stress pathways in aging and neurodegeneration should inspire innovative strategies to enhance the quality of life for the elderly and positively impact society

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