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In the published Phase 1/2 trial, CJC-1295 with DAC showed no serious adverse events at doses up to 60 mcg/kg

These findings provide critical insights into the role of CAFs in modulating anti-tumor immunity and highlight promising new avenues for developing more effective immunotherapeutic strategies for CRC

In addition to compositional markers, microbiota-derived metabolites provided functional insights: short-chain fatty acids (SCFAs) reduced airway eosinophil infiltration by binding to GPR41/43 and inhibiting histone deacetylase (HDAC), thereby reflecting the anti-inflammatory potential of the microbiota-host interaction

Niroula A, Khatri S, Timilsina R, Khadka D, Khadka A, Ojha P