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The cytoprotective effect of BPC 157 against colonic ischemia/reperfusion-mediated mucosal damage is associated with the activation of the collateral circulation, which circumvents obstructed sites and results in the resolution of the obstruction, reduction of oxidative stress and normalization of NO synthesis

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Results X-ray crystal structure of PGRMC1 We solved the crystal structure of the haem-bound PGRMC1 cytosolic domain (a.a.72195) at 1.95 resolution (Supplementary Fig