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In vitro studies showed that QUR and its derivative (isoquercetin) induced substantial neurotrophin (NGF) and BDNF-induced neurite outgrowth through activation of Na+/K+/2Cl-cotransporter isoform (NKCC1) (Nakajima et al., 2011) and modulate Rho GTPase enzyme activity (Palazzolo et al., 2012)

Following a 4- to 5-day recovery period, mice were fasted overnight and placed in rat-sized restrainers for acclimation

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