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In a study performed on Wistar rats, before Epitalon subcutaneous injection, rats were pinealectomized

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Nausea (most common, especially during first 1 to 2 weeks of a new dose) Diarrhea or, just as often, constipation Vomiting (less common but more likely at 9 to 12 mg) Reduced appetite, food noise quieting down (this is the goal, not a side effect) Skin sensitivity (dysesthesia): tingling, prickly feeling, or sunburn-like skin

The primary benefits of tirzepatideimproved glucose management and weight reductionremain the therapeutic focus, with creatine serving as an adjunct to support body composition goals when clinically appropriate