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Wilson disease is caused by mutations (e.g

The risk of biliary disease has been examined in fewer studies, which may be because gallbladder emptying is impaired

Initial preclinical and clinical studies have demonstrated ARA-290s broad therapeutic potential, particularly in conditions characterized by inflammation, tissue damage, and neuropathy

LiEHammCMGulatiASSartorRBChenHWuXet alInflammatory bowel diseases phenotype, C

Substitution of key leucine residues (L145, L149, and L152) in the hydrophobic interface with tryptophan (1933 and 2007), significantly reduced peptide activity, indicating that these leucine residues are required for interaction with the hydrophobic pockets of FAT