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Glutathione (GSH) is a highly specialized, endogenous tripeptide natively synthesized in nearly every cell of the human body

[1] This review focuses on glutathione as a skin-lightening agent

[DOI] [PMC free article] [PubMed] [Google Scholar] 206.Pavlov PF

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GSH biosynthesis is proposed to be regulated as a rheostat system that is designed to maintain sufficient antioxidant capacities, while preventing an overproduction of low molecular antioxidants that may interfere with the essential roles of ROS signaling ( Beyond the established benefits of NAC in some disorders, several trials in other disease conditions have shown inconsistent efficacy or no efficacy of GSH supplementation on outcomes, and the causal relationship of glutathione depletion to disease progression remains incompletely understood ( Our data add to a body of evidence that healthy aging is accompanied by elevated markers of cardiovascular risk, which included significantly increased levels of CRP, HOMA-IR, triglycerides, and cholesterol ( vs