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doi:10.1016/j.neuron.2012.07.010

Esser N, Paquot N, Scheen AL, Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease

The needle is very short (think insulin syringes), and doesnt go beyond the fat tissue

M., Klein R., et al

The bottom line: mechanistically sound doesn't mean clinically validated
