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As an example of such a multipronged approach, the Neotone formulation simultaneously targeting melanocytes, fibroblasts, and endothelial cells with the combination of five actives (niacinamide, licorice extract, diacetylboldine, a DKK1 agonist, and an inhibitor of EDN-1 synthesis) was found to be as effective as hydroquinone 4% cream in the management of facial melasma, while inducing fewer side effects [214]

doi: 10.1080/21655979.2022.2086351 55 MaoCLiuXZhangYLeiGYanYLeeHet al

Aldini G, Vistoli G, Stefek M, Chondrogianni N, Grune T, Sereikaite J, et al

Glutathione is composed of three essential amino acids: glutamine , glycine , and cysteine

Pinch a layer of skin with your thumb and index finger, which should be about an inch and a half apart from each other, in the front area of the thigh