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Skeletal muscle loss during multikinase inhibitors therapy: Molecular pathways, clinical implications, and nutritional challenges

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The receptors for activated Ckinases anchor proteins bind directly with the C2 domain of activated PKC but this has only been shown for PKC II and PKC .141, 142 There are other proteins described as forming proteinprotein interactions with PKC be it adapter proteins, anchor proteins or PKC substrates and these have great potential for therapeutic target development (reviewed in ref

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