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Lymphatic Research and Biology

This results in the accumulation of cytosolic Ca 2+ followed by activation of synaptic vesicle exocytosis, and release of neurotransmitters

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In turn, the impairment in -oxidation can shift the metabolism of VPA toward predominantly peroxisomal -oxidation, resulting in excessive production and accumulation of -oxidation products, including 4-en-VPA a metabolite that is incriminated in VPA-induced hepatotoxicity

Vilskersts R, Kigitovica D, Korzh S, et al