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10.1016/s0090-9556(24)15211-7 82 PanizoS.Martnez-AriasL.Alonso-MontesC.CannataP.Martn-CarroB.Fernndez-MartnJ

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Acute application of the metal decreased AMPA evoked currents (IC 50 = 22.9 M) compared to neurons treated with AMPA alone, in addition to decreasing synaptic activity

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Moreover, NAMPT activity is crucial for the beneficial effects of calorie restriction, including improved oxidative stress management, mitochondrial biogenesis, and metabolic adaptation, as reported in a study involving Sprague-Dawley rats 213

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