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10.1016/s0090-9556(24)15211-7 82 PanizoS.Martnez-AriasL.Alonso-MontesC.CannataP.Martn-CarroB.Fernndez-MartnJ

14 and 18
Acute application of the metal decreased AMPA evoked currents (IC 50 = 22.9 M) compared to neurons treated with AMPA alone, in addition to decreasing synaptic activity

Moreover, NAMPT activity is crucial for the beneficial effects of calorie restriction, including improved oxidative stress management, mitochondrial biogenesis, and metabolic adaptation, as reported in a study involving Sprague-Dawley rats 213

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