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4.4.2 Evidence of the effects of LOX on aging and senescence In general, LOX generates lipid hydroperoxides from PUFAs

[99] observed increased levels of self-grooming in Shank3 E13 and Cul3 f/ mice treated with GSK-LSD1 (a LSD1 inhibitor) or ORY-1001 (another LSD1 inhibitor) [99]

Cell morphology was observed using an inverted microscope (Leica, Germany)

Iron not only produces ROS directly, but also participates in the synthesis of iron-containing LOXs that oxidize polyunsaturated fatty acids (PUFAs) to result in lipid peroxides (Lei et al., 2019)

The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis
