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HEK293 cells were co-transfected with expression vectors for GST alone or the following GST-tagged MEIS1 deletions: MEIS1 N_HD (including the N-terminal and HD, boxed in black), MEIS1 HD (HD only, green) and MEIS1 C_HD (including the C-terminal and HD, dark gray) and FLAG-tagged HOXB1 (top) or V5-tagged GATA4 (bottom)

Front Aging Neurosci 14:827900

doi: 10.12968/jowc.2018.27.Sup9.S30 258 KolimiPNaralaSNyavanandiDYoussefAAADudhipalaN

The authors concluded in the abstract that IAPP toxic oligomers are formed intracellularly within the secretory pathway in T2DM