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The longest splicing variant of the SLC22A5 gene codes for an OCTN2 variant called OCTN2VT containing an insertion of 24 amino acids in the first extracellular loop, that seems to be localized in the ER (Figure 2

doi: 10.3389/fnut.2026.1676497 Received 30 July 2025 Revised 18 December 2025 Accepted 05 January 2026 Published 13 February 2026 Volume 13 - 2026 Edited by Senthil Kumaran Satyanarayanan, Hong Kong Institute of Innovation and Technology, Hong Kong SAR, China Reviewed by Luciene Bruno Vieira, Federal University of Minas Gerais, Brazil Iffet Ipek Bosgelmez, Erciyes University, Trkiye Updates Copyright 2026 Miteva, Laurenti, Mattioli, Di Risola, Mariano and Mosca

While short-term stress aids balance, prolonged activation disrupts neurogenesis, synaptic plasticity and structural integrity, increasing neuropsychiatric risks 126