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These miRNAs reside in intronic regions within SREBP-1 and 2, the key transcriptional regulators of lipid metabolism 87 , and control the expression of carnitine O -octanoyltransferase (CROT), CPT1A, hydroxyacyl coenzyme A (hydroxyacyl-CoA) dehydrogenase subunit beta (HADHB), and AMPK, targeting their 3 UTR 88
In the realm of drug development, focusing on key enzymes and transporters involved in ketone metabolism, such as BDH1 and SCOT, novel therapeutics could provide more targeted and effective treatment options for heart failure patients by targeting ketone metabolism pathways
A., Guo, U., Breslin, A., & Melville, L
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