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Fusion between healthy and damaged mitochondria dilutes the damaged mitochondria into the healthy mitochondrial lattice, which in turn maintains overall mitochondrial health (Twig et al., 2008)
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PDE5 inhibitors, such as sildenafil and tadalafil, have been shown to reduce hypoxic pulmonary vasoconstriction and arterial remodeling, suggesting a potential for these molecules in emphysema treatment [167]
