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The Morris water maze test and passive avoidance test are usually adopted to evaluate the bioavailability of peptides at the animal level (100), while in vitro experiments are used to explore the molecular mechanisms associated with the action of active peptides (101)
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These findings position SIRT7 as a potential therapeutic target for treating IBD, with the inhibition of its activity offering a novel approach to attenuating intestinal inflammation 194
Furthermore, increasing the concentration of MOTS-c alone does not trigger its nuclear translocation [36]
