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First, it is the major enzyme that oxidizes NADH to NAD +

Dystonia can affect individuals at any age, but it often manifests during childhood or early adulthood

This process is highly specific and dependent on the presence of the SECIS sequence in mRNA [100] and a specialized translation apparatus, enabling the incorporation of selenocysteine, among other things, in place of the UGA codon, which typically functions as a stop codon [101, 102]

In a follow-up report, the Chinnery laboratory argued that the discrepancy in the conclusions of the two Shoubridge laboratory studies was the result of the frequently extreme bias in the relative levels of the NZB versus the BALB mtDNAs, one mtDNA type always being present at a low percentage heteroplasmy
