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While some people feel more energized within hours, it typically takes 2472 hours to notice full effects, especially if youre deficient

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The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

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Serious but rare complications: Hypokalaemia: Rapid B12 replacement in severely deficient patients can precipitate potassium depletion during haematopoietic recovery, potentially causing cardiac arrhythmias