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These structural features are relevant for laboratory interpretation because they reduce some variables that complicate work with cyclic or disulfide-containing peptides, such as incorrect disulfide pairing, oxidative folding state, or multiple disulfide-linked isomers

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Any pedal edema appearing within weeks of initiation should prompt a CMP to check albumin and creatinine before attributing it to the peptide

Stefanova (FACS Core Facility, Biozentrum, University of Basel) for help with flow cytometry

however, this finding has not been followed up by intervention trials in humans