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Often referred to as the Master Antioxidant, GSH works to support detoxification, free radical damage, support immune funtion, and maintaining cellular health

The final hydroxylation step takes place in the renal proximal convoluted tubules, where the enzyme vitamin D-1-hydroxylase (CYP27B1) converts 25(OH)D into 1,25-dihydroxycholecalciferol (calcitriol), the biologically active form of vitamin D

doi: 10.1016/j.canlet.2008.02.026

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Notably, PUFAs in neuronal membranes are primary targets for lipid peroxidation, with ROS derived from mitochondrial metabolism and NADPH oxidases further amplifying oxidative stress (28) (Figure 3)