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Regardless of the etiological factor(s) leading to the onset of NAFLD, the increased flow of free fatty acids to the liver concurrently increases oxidative stress and suppresses hepatic intracellular antioxidant activity [1]

Indeed, with respect to diabetes, several mitochondrial diseases manifest with diabetic complications such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) and maternally inherited diabetes and deafness (MIDD)

PanditRJHinsuATPatelNVKoringaPGJakhesaraSJThakkarJRet al

While aging plays a role, cellular health matters too

Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis