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It is not unusual to experience some mild tingling and irritation during the first few weeks

Levine, M., Rumsey, S

2023 Jul;27(14):6718-6727

This is due to its low oral bioavailability, which, combined with its swift metabolism, accounts in large part for why in vitro results do not always translate well clinically (Xu et al., 2022)

However, several case studies actually show Suboxone reversing heroin overdoses