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Description
Key limitations include poorly characterized pharmacokinetics (rapid absorption but extensive metabolism and low systemic bioavailability for eugenol), variable extract standardization, heterogeneous assay methodologies, and limited in vivo and clinical data
Small-molecule-directed hepatocyte-like cell differentiation of human pluripotent stem cells
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This route is particularly valuable for targeting the central nervous system, as it allows certain peptides and proteins to bypass the bloodbrain barrier (BBB), which typically restricts entry of large or hydrophilic molecules into the brain
