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Conversely, zinc supplementation can mitigate this effect by inhibiting caspase-3, 6, 7 and 8, thereby reducing apoptosis [315]

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In some terrestrial hypoxia-tolerant species, the antioxidase activity has also shown a similar trend, such as the activity of CAT and SOD being significantly higher in the heart and liver of Tibetan pigs than in DLY pigs (the Duroc (Landrace Yorkshire) hybrid pig) ( Heterocephalus glaber ) ( Researchers have uncovered some related genes or gene families that play a role in the adaptive evolutionary mechanisms of hypoxia-tolerant mammals

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