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Vanishing white matter disease is an autosomal recessive, polygenic disorder caused by mutations in five genes ( EIF2B1 , EIF2B2 , EIF2B3 , EIF2B4 and EIF2B5 ) encoding the eukaryotic translation initiation factor eIF2B, a key control point for protein synthesis in all eukaryotes 335

Expect modest changesnot a dramatic fat loss effect

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Notably, OS plays a pivotal role in the pathophysiology of MI

Although studies from North and South American populations have not consistently identified biological sex-biased differences in LOAD incidence, research conducted in Europe and Asia suggests a higher incidence of the disease among women, particularly those older than 80 years 3,4