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(b) Parameter sensitivity analysis of VCAT on glutathione (GSH) in the integrated oxidative stress and C1 metabolism model

LPS binds to Toll-like receptor 4 (TLR4) on the surface of Kupffer cells, activating both the MyD88-dependent pathway, which mediates NF-B signaling, and the MyD88-independent pathway involving interferon regulatory factor 3 (IRF3), ultimately upregulating TNF- transcription [49, 50]

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Patients with contraindications or non-responsive to NSAIDs may benefit from opioids such as meperidine [114], butorphanol [115], or hydromorphone [110]

Reversal of severe neurological abnormalities after vitamin B12 replacement in the Imerslund-Grasbeck syndrome