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However, adoptive transfer of T-cells from Drd5 knockout mice showed that D5-specific signaling enhanced the suppressive activity of murine T regs in vivo and increased the expression of glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) (Osorio-Barrios et al., 2018)

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The increase in these enzymes enhances the cells antioxidant capacity, reducing oxidative stress by neutralizing ROS

Abbreviations VNS: Vagus nerve stimulation I/R: Ischemiareperfusion ALT: Alanine aminotransferase AST: Aspartate aminotransferase cTnI: Cardiac troponin I ROS: Reactive oxygen species MDA: Malondialdehyde SOD: Superoxide dismutase GSH: Glutathione GPX4: Glutathione peroxidase-4 xCT: Cystine-glutamate antiporter system PUFAs: Polyunsaturated fatty acids AMPK: AMP-activated protein kinase References Jimenez-Castro MB, Cornide-Petronio ME, Gracia-Sancho J, Peralta C

Alpha-Lipoic acid: An antioxidant with anti-aging properties for disease therapy