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When CaM from two molecules combines, eNOS becomes activated and leads to the conversion of O 2 to NO and L-Arg to L-citrulline (170)

In some cases the phenotype is linked to mislocalization of the pigments to the cytoplasm 29 or vesicle-like structures 19,30

Glutathione is often referred to as the bodys master antioxidant due to its ability to neutralize free radicals and support detoxification processes

Sequences of qPCR primers can be found in Supplementary Table 5

The symptoms of peripheral neuropathy vary but are often described as pain, tingling (pins and needles sensation), burning, numbness, reduced sensation, trembling, tripping or stumbling when walking, difficulty in picking up small objects, and sensitivity to temperature