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In the presence of oxidative stress or specific electrophilic stimuli , critical cysteine residues on KEAP1 undergo modifications that disrupt KEAP1-mediated repression, resulting in the stabilization and release of Nrf2

Oral bioavailability of peptides is notoriously low due to enzymatic degradation in the GI tract

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AOD-9604 vs Alternatives Compared to GHRH analogs such as tesamorelin or CJC-1295, which act upstream by stimulating pituitary GH release and downstream IGF-1, AOD-9604 operates further down the pathway with a narrower receptor footprint