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Description
Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 17,18,19,20
Most current mRNA therapeutics rely on lipid nanoparticles (LNPs) carriers administered intramuscularly or intravenously
Table S1)
S9B, Supporting Information)
Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes
