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Differences in pharmacokinetic profiles are apparent between experimental animals and humans

Care 30 (6), 473483 (1992)

A chaperone is usually a small molecule that restores the correct folding of mutant enzymes, facilitating their trafficking to the lysosomes and thus increasing the residual enzyme activity

2018 June 115 :142-149

Neurochem Res 33:25402546 Ansari MA, Joshi G, Huang Q, Opii WO, Abdul HM, Sultana R, Butterfield DA (2006) In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimers disease and other oxidative stress-related neurodegenerative disorders