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Notwithstanding the small numbers of studies, current evidence confirms safety and good tolerability following the utilization of GalNAc 3 conjugated nucleic acids [81, 83,84,85]

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Lower IGF-1 Levels correlate with liver dysfunction, fibrogenesis, and mortality in ACLD, primarily through disrupted bone remodeling, marked by reduced osteoblast activity and prolonged osteoclast lifespan[28,29]

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