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Another study reported the interplay between ROS and SIRT1 in cell death during EV71 infection, and inhibition of ROS by NAC was shown to reduce EV71 propagation 149

however, recent studies suggest that the condition is more common than previously recognized [5]
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doi: 10.1093/bib/bbae275

However, some orally-administered drugs are able to avoid first-pass metabolism , to some degree at least, as a result of lymphatic drug absorption
