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This is a localized reaction with redness, pain, tenderness, and swelling at the injection site that occurson average seven to 10 days after vaccination , says Hana El Sahly, M.D., an associate professor of molecular virology and microbiology at Baylor College of Medicine in Houston and a national co-principal investigator of the phase 3 clinical trial for the Moderna vaccine

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For long-term studies or to prevent degradation from repeated freeze-thaw cycles, it is best practice to aliquot the freshly reconstituted solution into single-use volumes and store them frozen at -20C or colder