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Cobalamin defects C, D, and F are due to defective synthesis of both methylcobalamin (resulting in hyperhomocysteinemia and hypomethioninemia) and adenosylcobalamin (resulting in methylmalonic aciduria) (216)

Primary Care Guidelines for B12 and Folate Testing Indications for B12 and Folate Testing No need to check B12 levels in patient on parenteral B12 treatment (they will always be high) There is no indication to check GPA or INF purely because of family history of autoimmune disease or hypothyroidism Care should be taken when prescribing folic acid alone If folic acid is given to a patient who is actually b12 deficient, this may precipitate irreversible neurological complications References 1

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