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Berberine has demonstrated its anti-inflammatory effects through the activation of AMPK-dependent autophagy in adipose tissue macrophages (ATMs), which leads to a reduction in urinary IL-1 levels in diabetic mice (136)
Therefore, further investigation is required to determine optimal safe and efficacious doses of the currently clinically available NAD + precursors
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44 (1) e202400186
doi: 10.1002/mnfr.201801231
