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Additionally, patients may have a variety of other neurological symptoms, such as vertigo, dizziness, tinnitus, and cognitive impairment, and MD often begins with premonitory symptoms hours or days before pain onset [60]

Moreover, because circulating LCAC levels often correlate with disease severity, NYHA class, and are reduced by surgical intervention, continued monitoring of a CVD patients metabolome could provide insight into the progression or regression of the disease (Hunter et al., 2016

Valproic acid-induced hyperammonaemic coma and unrecognised portosystemic shunt

There is a large microbial community in the human gut, and at least 20% of small molecules in the human blood are products of the microbiome, which plays a vital role in our physiology and metabolism (Rook et al., 2017)

The proposed potential mechanisms for L-carnitines cardiovascular benefits have been the focus of much research