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In addition to this, treatment of A549 and H3122 cells with SAG caused an increase in intracellular Fe 2+ concentration, ROS levels and MDA content as well as a decrease in GSH content, which was thus shown to also trigger ferroptosis in lung cancer [217]
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In human CECs (HCECs) exposed to phenylarsine oxide (PAO), a highly toxic trivalent arsenical, significant oxidative stress was reported by Kandhari et al., accompanied by ferroptotic cell death (115)
2010;5:e8579
