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10.1038/s41467-021-27758-8 41 HuangW.ManY.GaoC.ZhouL.GuJ.XuH.et al (2020)

Therefore, we hypothesize that the proposed dual-functions transdermal drug delivery system can be achieved via poloxamer-based hydrogel

Because it does not suppress the body's natural hormone production (unlike exogenous hormones), it is considered to have a clean systemic safety profile in the context of the available data

Through interconversion of NADP/NAD, the availability of GSH thus allows the cell to stabilize the NAD+/NADH ratio and NAD levels in the face of increased NAD+ consumption by enzymatic processes during wakefulness