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Example of ED Buprenorphine-Naloxone order set Relative Contraindications to ED Buprenorphine-Naloxone Initiation Allergy to either buprenorphine or naloxone Hepatic dysfunction Respiratory distress currently Decreased LOC currently Concurrent active alcohol use disorder Concurrent benzodiazepine use Learn more about Buprenorphine in the ED in EMU 365: Expanding Our Scope- ED Initiated Buprenorphine Treatment of opioid withdrawal symptoms for those who do not fulfill criteria for Buprenorphine-Naloxone If the patient either does not meet criteria for opioid use disorder, or does not want to start Buprenorphine-Naloxone, counsel them regarding their risks and provide symptomatic relief for withdrawal symptoms

To maintain redox homeostasis, cells have developed diverse antioxidant pathways to counteract ROS (Figure 1)

Hematocrit, reticulocyte count, vitamin B 12 , folate, and iron levels should be obtained prior to treatment

Water-Mediated Hydrophobic Interactions

[DOI] [PubMed] [Google Scholar] Lu SC, Mato JM