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Blood 94 , 29552962 (1999)

In response to increased plasma Hcy concentrations, there may be vascular endothelial dysfunction, reduced expression of thrombomodulin and activated protein C [64], a decrease in the presence of anticoagulant heparans [65], and a decrease in tissue plasminogen activator receptors on the surface of vascular endothelial cells [66]

Engagement of -glucans with Dectin-1 triggers tyrosine phosphorylation of an immunoreceptor tyrosine activation (ITAM)-like motif, which in turn recruits and activates the Syk tyrosine kinase, leading to activation of both NF-B and MAPKs through a signaling pathway mediated by Card9 and Raf (9, 1214)

Diabetes Care 48 , 18781887 (2025)