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Extracellular vesicles, particularly exosomes, within the secretome are key players, acting as natural nanocarriers to deliver proteins, lipids, and microRNAs to target cells, thereby mediating these therapeutic effects

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In one embodiment, the antibody or antigen binding portion thereof according to the present invention binds an antigen (e.g., ALPP and/or ALPPL2) or a cell expressing the antigen with an affinity (K D ) of 5 nM or better (i.e., or less) (e.g., 40 nM or 30 nM or 20 nM or 10 nM or less), as measured using a surface plasmon resonance assay or a cell binding assay