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doi:10.1177/2050640614560786 McDowell CP, Dishman RK, Gordon BR, Herring MP

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1 2 Annual Review of Nutrition

EZH2 inhibitors have demonstrated efficacy in various hematologic and solid tumors, with their mechanisms of reversing resistance primarily involving the reactivation of silenced target genes, alteration in cell differentiation states, and modulation of the tumor immune microenvironment [251, 252]