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In the BAT of HFD-fed mice, treatment with GA elevated the expression of SIRT1 and PGC1-alpha mRNA, enhancing thermogenesis and improving overall body metabolism (Paraso et al., 2019)

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Frye R.E., Sreenivasula S., Adams J.B
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The proteins are enzymatically hydrolyzed, and after enzyme inactivation the solution is purified and filtered

Paul and Brady also note that various single-nucleotide polymorphisms (SNPs) may influence the efficacy and bioavailability, but that at this time there is neither sufficient clinical research in this area nor are tests for these SNPs commercially available
